The Genomic Information Commons (GIC) is a continuously updating, queryable, federated genomic data commons. Inspired by a common vision of accelerated genomic research discovery, collaboration and improved clinical outcomes, leaders at Boston Children’s Hospital (BCH), Harvard Medical School, Cincinnati Children’s Hospital Medical Center (CCHMC), the Children’s Hospital of Philadelphia (CHOP), St. Louis Children’s Hospital (SLCH)/Washington University at St. Louis (WUSTL) and the University of Pittsburgh Medical Center (UPMC) have come together to create the GIC. The GIC has established highly scalable technologies, policies, and procedures for sharing genomic data, phenotypic data and biospecimen metadata on broadly consented cohorts, across sites of care.